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Carbapenems Bacteriostatic or Bactericidal
On Bacteriostatic or Sterilization of Carbapenems
Carbapenems, in the field of antibacterial, have different opinions on their antibacterial and bactericidal properties. Here is a detailed discussion.
Carbapenems have a unique chemical structure and can be closely linked to the penicillin-binding protein in the bacterial cell wall. The binding force is like a tenon-mortise fit, making the synthesis of the bacterial cell wall unsustainable. The bacterial cell wall, like a city in a country, loses its strength, and the bacteria are vulnerable to a single attack.
Looking at its mechanism of action, it tends to be bactericidal. It has powerful killing ability against many gram-positive and negative bacteria. In case of negative bacteria such as Klebsiella pneumoniae and Escherichia coli, carbapenems directly attack Huanglong, causing the bacterial cell wall to disintegrate and cut off vitality. In the face of positive bacteria such as Staphylococcus aureus, it is also like a sharp blade breaking bamboo, making it difficult for bacteria to escape their execution.
However, there are also views that in certain situations, such as high bacterial concentration or sub-optimal drug concentration, carbapenems may be bacteriostatic. This situation is like surrounding but not destroying, although it inhibits the reproduction of bacteria, it does not eliminate its roots.
In summary, carbapenems usually exhibit strong bactericidal activity, but under special circumstances, they may also have bacteriostatic performance. When a doctor uses medication, he should distinguish the pharmacology and evaluate the situation in order to achieve accurate treatment and eliminate bacteria.
Carbapenems, in the field of antibacterial, have different opinions on their antibacterial and bactericidal properties. Here is a detailed discussion.
Carbapenems have a unique chemical structure and can be closely linked to the penicillin-binding protein in the bacterial cell wall. The binding force is like a tenon-mortise fit, making the synthesis of the bacterial cell wall unsustainable. The bacterial cell wall, like a city in a country, loses its strength, and the bacteria are vulnerable to a single attack.
Looking at its mechanism of action, it tends to be bactericidal. It has powerful killing ability against many gram-positive and negative bacteria. In case of negative bacteria such as Klebsiella pneumoniae and Escherichia coli, carbapenems directly attack Huanglong, causing the bacterial cell wall to disintegrate and cut off vitality. In the face of positive bacteria such as Staphylococcus aureus, it is also like a sharp blade breaking bamboo, making it difficult for bacteria to escape their execution.
However, there are also views that in certain situations, such as high bacterial concentration or sub-optimal drug concentration, carbapenems may be bacteriostatic. This situation is like surrounding but not destroying, although it inhibits the reproduction of bacteria, it does not eliminate its roots.
In summary, carbapenems usually exhibit strong bactericidal activity, but under special circumstances, they may also have bacteriostatic performance. When a doctor uses medication, he should distinguish the pharmacology and evaluate the situation in order to achieve accurate treatment and eliminate bacteria.
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