Langyou Chemical
SUPPLEMENTS
Gentamicin Bactericidal Mechanisms
Gentamicin has a bactericidal effect, and its bactericidal mechanism is quite critical. Gentamicin can specifically bind to the 30S subunit of bacterial ribosome, interfering with the initial stage of bacterial protein synthesis, which hinders the formation of the starting complex and makes it difficult to start protein synthesis normally. At the same time, in the peptide chain extension stage, gentamicin can cause mRNA code mistranslation, synthesizing abnormal and non-functional proteins. These abnormal proteins not only fail to play normal physiological roles, but also may interfere with the normal metabolic process of bacteria and cause damage to bacteria. In addition, gentamicin may also affect the integrity of bacterial cell membranes, increasing the permeability of cell membranes, outflow important substances in cells, and further damage the living environment of bacteria, eventually leading to bacterial death. These various mechanisms cooperate with each other to establish the bactericidal ability of gentamicin and play an important role in the field of antibacterial.
Scan to WhatsApp
