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How Does Penicillin Act As A Bactericidal Agent Quizlet
Penicillin is a commonly used antibacterial drug, and its mechanism of action as a bactericide is crucial. Penicillin mainly acts on the synthesis process of bacterial cell walls.
Bacterial cell walls are essential for maintaining the stability of bacterial morphology, structure and function. The beta-lactam ring contained in penicillin binds closely to the transpeptidase required in the synthesis process of bacterial cell walls. This binding results in the inactivation of transpeptidase, which plays an indispensable role in the cross-linking of peptidoglycans, a key step in cell wall synthesis. Once transpeptidase activity is lost, peptidoglycans cannot be cross-linked normally, and the synthesis of bacterial cell walls is seriously hindered. After the cell wall is damaged, the bacteria cannot maintain their normal shape and structure. Under the influence of external osmotic pressure and other factors, the bacteria are prone to swell, rupture, and eventually die. This is the main way that penicillin plays a bactericidal role. By interfering with the key link of bacterial cell wall synthesis, it shows strong killing ability to many bacteria, which is of great significance in the field of antibacterial treatment.
Bacterial cell walls are essential for maintaining the stability of bacterial morphology, structure and function. The beta-lactam ring contained in penicillin binds closely to the transpeptidase required in the synthesis process of bacterial cell walls. This binding results in the inactivation of transpeptidase, which plays an indispensable role in the cross-linking of peptidoglycans, a key step in cell wall synthesis. Once transpeptidase activity is lost, peptidoglycans cannot be cross-linked normally, and the synthesis of bacterial cell walls is seriously hindered. After the cell wall is damaged, the bacteria cannot maintain their normal shape and structure. Under the influence of external osmotic pressure and other factors, the bacteria are prone to swell, rupture, and eventually die. This is the main way that penicillin plays a bactericidal role. By interfering with the key link of bacterial cell wall synthesis, it shows strong killing ability to many bacteria, which is of great significance in the field of antibacterial treatment.
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