Langyou Chemical
SUPPLEMENTS
Ph Temperature Sensitive Polymers for Macromolecular Drug Loading and Release
On pH and Temperature Sensitive Polymers for Macromolecular Drug Delivery
I. INTRODUCTION
Drug delivery is related to the rehabilitation of patients and the importance of doctors. Nowadays, pH and temperature sensitive polymers have emerged in the field of macromolecular drug delivery, opening up a new path for the development of medicine.
II. Characteristics of pH and Temperature Sensitive Polymers
Such polymers have unique responses. When the pH of the environment changes, or the temperature rises and falls, its molecular structure and properties change accordingly. For example, pH sensitive, at a specific pH value, the chain conformation can be changed, or swollen, or contracted. Temperature sensitive, the critical temperature is reached, and there is also a phase transition, which makes it suitable for drug delivery.
III. For macromolecular drugs
macromolecular drugs, often due to size and nature, it is difficult to reach the target. pH and temperature sensitive polymers can be carriers and contain drugs. With its unique structure, macromolecular drugs are included in it by physical adsorption, chemical bonding, etc. And the polymer can protect the drug from inactivation during transportation and ensure the retention of drug efficacy.
IV. Release of macromolecular drugs
When the polymer drug-carrying system reaches the target tissue, the pH or temperature of the target area is different from the normal, triggering the polymer response. If the tumor site is often acidic, the pH-sensitive polymer is in this environment, the structure is broken, and the drug is released. For example, during local hyperthermia, the temperature rises, the phase of the temperature-sensitive polymer changes, and the drug is also released, which precisely acts on the lesion.
V. Advantages and Prospects
The use of such polymers for macromolecular drug delivery has the advantages of targeted accuracy and good controlled release. It can reduce the harm of drugs to normal tissues and increase the curative effect. Looking to the future, with in-depth research, it will be able to optimize the properties of polymers, expand applications, and add bricks to the pharmaceutical industry, benefiting more patients.
I. INTRODUCTION
Drug delivery is related to the rehabilitation of patients and the importance of doctors. Nowadays, pH and temperature sensitive polymers have emerged in the field of macromolecular drug delivery, opening up a new path for the development of medicine.
II. Characteristics of pH and Temperature Sensitive Polymers
Such polymers have unique responses. When the pH of the environment changes, or the temperature rises and falls, its molecular structure and properties change accordingly. For example, pH sensitive, at a specific pH value, the chain conformation can be changed, or swollen, or contracted. Temperature sensitive, the critical temperature is reached, and there is also a phase transition, which makes it suitable for drug delivery.
III. For macromolecular drugs
macromolecular drugs, often due to size and nature, it is difficult to reach the target. pH and temperature sensitive polymers can be carriers and contain drugs. With its unique structure, macromolecular drugs are included in it by physical adsorption, chemical bonding, etc. And the polymer can protect the drug from inactivation during transportation and ensure the retention of drug efficacy.
IV. Release of macromolecular drugs
When the polymer drug-carrying system reaches the target tissue, the pH or temperature of the target area is different from the normal, triggering the polymer response. If the tumor site is often acidic, the pH-sensitive polymer is in this environment, the structure is broken, and the drug is released. For example, during local hyperthermia, the temperature rises, the phase of the temperature-sensitive polymer changes, and the drug is also released, which precisely acts on the lesion.
V. Advantages and Prospects
The use of such polymers for macromolecular drug delivery has the advantages of targeted accuracy and good controlled release. It can reduce the harm of drugs to normal tissues and increase the curative effect. Looking to the future, with in-depth research, it will be able to optimize the properties of polymers, expand applications, and add bricks to the pharmaceutical industry, benefiting more patients.
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