Langyou Chemical
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Stearic Acid in Tablets
On the application of stearic acid in tablets
The preparation of capping tablets, the material compatibility, exquisite technology, is very important to the efficacy and quality. Stearic acid is useful in the production of tablets.
For stearic acid, it is solid at room temperature and has certain lubricity. In the preparation of tablets, it is often used as a lubricant. It can reduce the friction between the material and the die, so that the tableting process is smooth, the appearance of the tablet is smooth, and there is no risk of cracking or sticking. If the material fluidity is not good, it is easy to cause a large difference in the weight of the tablet during tableting. Stearic acid can improve this situation, so that the material is evenly filled in the die hole and the sheet weight is stable.
However, its use also needs to be cautious. The dosage is too small, the lubrication is insufficient, and the tablet is difficult to press. Too much dosage may cause the tablet to disintegrate slowly, and the drug dissolution will be hindered, which will affect the curative effect. Therefore, during the preparation, the dosage of stearic acid needs to be accurately controlled according to factors such as material characteristics, tablet type, and equipment.
Furthermore, stearic acid is chemically stable and has no adverse reactions with most drugs, but there are exceptions. Some acid-sensitive drugs may degrade due to the presence of stearic acid, which will damage the efficacy. At this time, it is necessary to study the properties of the drug in detail, choose another suitable excipient, or adjust the process to avoid its adverse effects.
In short, stearic acid is an indispensable excipient for tablet production. Appropriate use can improve the quality and efficacy of tablets; improper use will cause a lot of harm. The producer should understand its properties and know its methods to achieve the state of excellent tablets.
The preparation of capping tablets, the material compatibility, exquisite technology, is very important to the efficacy and quality. Stearic acid is useful in the production of tablets.
For stearic acid, it is solid at room temperature and has certain lubricity. In the preparation of tablets, it is often used as a lubricant. It can reduce the friction between the material and the die, so that the tableting process is smooth, the appearance of the tablet is smooth, and there is no risk of cracking or sticking. If the material fluidity is not good, it is easy to cause a large difference in the weight of the tablet during tableting. Stearic acid can improve this situation, so that the material is evenly filled in the die hole and the sheet weight is stable.
However, its use also needs to be cautious. The dosage is too small, the lubrication is insufficient, and the tablet is difficult to press. Too much dosage may cause the tablet to disintegrate slowly, and the drug dissolution will be hindered, which will affect the curative effect. Therefore, during the preparation, the dosage of stearic acid needs to be accurately controlled according to factors such as material characteristics, tablet type, and equipment.
Furthermore, stearic acid is chemically stable and has no adverse reactions with most drugs, but there are exceptions. Some acid-sensitive drugs may degrade due to the presence of stearic acid, which will damage the efficacy. At this time, it is necessary to study the properties of the drug in detail, choose another suitable excipient, or adjust the process to avoid its adverse effects.
In short, stearic acid is an indispensable excipient for tablet production. Appropriate use can improve the quality and efficacy of tablets; improper use will cause a lot of harm. The producer should understand its properties and know its methods to achieve the state of excellent tablets.
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