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Trimethoprim Bacteriostatic or Bactericidal
On the bacteriostatic or bactericidal properties of trimethoprim
Those who talk about drugs in the world often have doubts about the properties of trimethoprim. Is it bacteriostatic or bactericidal? This is related to the accuracy of medication and the effectiveness of treatment of diseases, and cannot be discussed in detail.
The mechanism of action of trimethoprim is unique. It can inhibit bacterial dihydrofolate reductase, making it difficult to convert dihydrofolate into tetrahydrofolate. And tetrahydrofolate is necessary for bacteria to synthesize nucleic acid. This enzyme is inhibited, and the path of bacterial nucleic acid synthesis is blocked.
Looking at its bacteriostatic effect, when the concentration of methoxybenzidine is low, although the growth of bacteria is hindered, it does not cause disaster. The metabolism and reproduction rate of bacteria slow down, and it seems to fall into a dormant state. This is a sign of bacteriostatic. It is like a trapped beast in a cage, although it is temporarily free, it still has vitality.
As for the bactericidal power, if the concentration of methoxybenzidine increases, or when it works synergistically with other drugs, its power increases greatly. Bacteria are seriously damaged due to nucleic acid synthesis, their physiological functions collapse, and eventually die. This is the appearance of sterilization. Just like a raging fire, wherever it passes, nothing remains.
Or there is a question: "How do you know that there is such a change between bacteriostatic and bactericidal?" Evidence can be found in both experiments and clinical practice. In the laboratory, different concentrations of trimethoprim act on bacteria, and the growth curve of trimethoprim can be clearly seen. The difference between low concentration bacteriostatic and high concentration bactericidal can be clearly seen. In clinical treatment, reasonable compatibility and proper drug use can often achieve a good effect of sterilization; if the drug is not used properly, the bacteria are only inhibited, and it is easy to cause repeated diseases.
From this perspective, trimethoprim has both bacteriostatic and bactericidal properties, and its performance varies with concentration and drug compatibility. When a doctor uses medication, he must carefully observe the condition, consider the dosage, and match it reasonably in order to maximize the effectiveness of this medication and help patients get rid of the pain of the disease as soon as possible.
Those who talk about drugs in the world often have doubts about the properties of trimethoprim. Is it bacteriostatic or bactericidal? This is related to the accuracy of medication and the effectiveness of treatment of diseases, and cannot be discussed in detail.
The mechanism of action of trimethoprim is unique. It can inhibit bacterial dihydrofolate reductase, making it difficult to convert dihydrofolate into tetrahydrofolate. And tetrahydrofolate is necessary for bacteria to synthesize nucleic acid. This enzyme is inhibited, and the path of bacterial nucleic acid synthesis is blocked.
Looking at its bacteriostatic effect, when the concentration of methoxybenzidine is low, although the growth of bacteria is hindered, it does not cause disaster. The metabolism and reproduction rate of bacteria slow down, and it seems to fall into a dormant state. This is a sign of bacteriostatic. It is like a trapped beast in a cage, although it is temporarily free, it still has vitality.
As for the bactericidal power, if the concentration of methoxybenzidine increases, or when it works synergistically with other drugs, its power increases greatly. Bacteria are seriously damaged due to nucleic acid synthesis, their physiological functions collapse, and eventually die. This is the appearance of sterilization. Just like a raging fire, wherever it passes, nothing remains.
Or there is a question: "How do you know that there is such a change between bacteriostatic and bactericidal?" Evidence can be found in both experiments and clinical practice. In the laboratory, different concentrations of trimethoprim act on bacteria, and the growth curve of trimethoprim can be clearly seen. The difference between low concentration bacteriostatic and high concentration bactericidal can be clearly seen. In clinical treatment, reasonable compatibility and proper drug use can often achieve a good effect of sterilization; if the drug is not used properly, the bacteria are only inhibited, and it is easy to cause repeated diseases.
From this perspective, trimethoprim has both bacteriostatic and bactericidal properties, and its performance varies with concentration and drug compatibility. When a doctor uses medication, he must carefully observe the condition, consider the dosage, and match it reasonably in order to maximize the effectiveness of this medication and help patients get rid of the pain of the disease as soon as possible.
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