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Types Of Bactericidal Antibiotics
Types of bactericidal antibiotics
Husband bactericidal antibiotics are also powerful tools for doctors to treat diseases. There are various types of them, and their functions are unique. They are the key to treating diseases and diseases.
First of all, there are beta-lactamides. This type of antibiotic contains a beta-lactam ring in its structure, which is like a sharp blade and can break the cell wall of bacteria. Its mechanism of action is to combine with the penicillin-binding protein required for the synthesis of the bacterial cell wall, blocking its cross-linking, causing the synthesis of the cell wall to be blocked, and the bacteria died due to the imbalance of osmotic pressure. Common ones, such as penicillin family and cephalosporins. Penicillin has been around for a long time and has made outstanding achievements. It has a good effect on the infection of a variety of Gram-positive bacteria; cephalosporins have continued to evolve. From the first generation to the fourth generation, the antibacterial spectrum has gradually broadened, and it has powerful lethality to both Gram-positive and Gram-negative bacteria. It has better stability and fewer side effects.
Aminoglycosides are also important bactericidal antibiotics. They can combine with the 30S subunit of bacterial ribosome to interfere with the initiation, extension and termination of bacterial protein synthesis, so that bacteria cannot grow and reproduce normally. These antibiotics have a wide antibacterial spectrum and are particularly effective against aerobic Gram-negative bacteria. However, their ototoxicity and nephrotoxicity should not be underestimated. When using drugs, it should be carefully weighed.
Quinolone antibiotics are mainly used to inhibit bacterial DNA rotatase or topoisomerase IV, so that bacterial DNA replication and transcription are blocked, and then apoptosis. Its antibacterial activity is high, and the antibacterial spectrum covers Gram-positive and negative bacteria. Some varieties are also effective against anaerobic bacteria. And it is well absorbed orally, has a wide tissue distribution, and has a wide range of clinical applications. However, it should be used with caution in minors because it can affect cartilage development.
In addition, glycopeptide antibiotics such as vancomycin have strong bactericidal power against Gram-positive bacteria, especially against methicillin-resistant Staphylococcus aureus and other severely drug-resistant bacteria. It acts on the late stage of peptidoglycan synthesis in bacterial cell walls and hinders the formation of cell walls. Although the curative effect is significant, there are many adverse reactions, and the blood concentration needs to be closely monitored.
All these bactericidal antibiotics have their own characteristics. Doctors should understand their pharmacology, review the patient's condition, weigh the pros and cons, and use drugs rationally in order to maximize their bactericidal and disease-removing effects and protect the health of common people.
Husband bactericidal antibiotics are also powerful tools for doctors to treat diseases. There are various types of them, and their functions are unique. They are the key to treating diseases and diseases.
First of all, there are beta-lactamides. This type of antibiotic contains a beta-lactam ring in its structure, which is like a sharp blade and can break the cell wall of bacteria. Its mechanism of action is to combine with the penicillin-binding protein required for the synthesis of the bacterial cell wall, blocking its cross-linking, causing the synthesis of the cell wall to be blocked, and the bacteria died due to the imbalance of osmotic pressure. Common ones, such as penicillin family and cephalosporins. Penicillin has been around for a long time and has made outstanding achievements. It has a good effect on the infection of a variety of Gram-positive bacteria; cephalosporins have continued to evolve. From the first generation to the fourth generation, the antibacterial spectrum has gradually broadened, and it has powerful lethality to both Gram-positive and Gram-negative bacteria. It has better stability and fewer side effects.
Aminoglycosides are also important bactericidal antibiotics. They can combine with the 30S subunit of bacterial ribosome to interfere with the initiation, extension and termination of bacterial protein synthesis, so that bacteria cannot grow and reproduce normally. These antibiotics have a wide antibacterial spectrum and are particularly effective against aerobic Gram-negative bacteria. However, their ototoxicity and nephrotoxicity should not be underestimated. When using drugs, it should be carefully weighed.
Quinolone antibiotics are mainly used to inhibit bacterial DNA rotatase or topoisomerase IV, so that bacterial DNA replication and transcription are blocked, and then apoptosis. Its antibacterial activity is high, and the antibacterial spectrum covers Gram-positive and negative bacteria. Some varieties are also effective against anaerobic bacteria. And it is well absorbed orally, has a wide tissue distribution, and has a wide range of clinical applications. However, it should be used with caution in minors because it can affect cartilage development.
In addition, glycopeptide antibiotics such as vancomycin have strong bactericidal power against Gram-positive bacteria, especially against methicillin-resistant Staphylococcus aureus and other severely drug-resistant bacteria. It acts on the late stage of peptidoglycan synthesis in bacterial cell walls and hinders the formation of cell walls. Although the curative effect is significant, there are many adverse reactions, and the blood concentration needs to be closely monitored.
All these bactericidal antibiotics have their own characteristics. Doctors should understand their pharmacology, review the patient's condition, weigh the pros and cons, and use drugs rationally in order to maximize their bactericidal and disease-removing effects and protect the health of common people.
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